Studies of oxazolobenzodiazepines. Part 7. Synthesis of 3-methyloxazolo[3,2-d][1,4]benzodiazepines and configurational studies of their ketimine intermediates
Abstract
Some 3-substituted oxazolo[3,2-d][1,4]benzodiazepines have been synthesized by a novel double-cyclization reaction, and the geometrical configurations of their ketimine intermediates have been investigated by n.m.r. spectroscopy and X-ray analysis.