8-Quinolyl esters of nucleoside 5′-phosphates. Part 2. Application to the synthesis of oligodeoxyribonucleotides bearing a 5′-phosphate end group

Abstract

8-Quinolyl nucleoside 5′-phosphates were easily prepared in high yields by the reaction of 8-hydroxyquinoline with nucleoside 5′-phosphates in the presence of di-2-pyridyl diselenide and triphenyl phosphite. The 8-quinolyl group was effective as a protecting group for the 5′-phosphate systems of nucleotides in the synthesis of deoxyribo-oligonucleotides.