Cleavage of the aminoadipoly side chain of cephamycin C to the (6R, 7S)-7-amino-7-methoxy derivative
Abstract
(6R,7S)-Benzhydryl 7-amino-7-methoxy-3-carbamoyloxymethylceph-3-em-4-carboxylate (6a), which is an important intermediate for the synthesis of various analogues with a wide spectrum of antibiotic activity, has been obtained from cephamycin C (1a)via the oxamic acid intermediate (3a).