Issue 3, 1978

Antitumour alkaloids of the vinblastine-type: is leurosine an artefact?

Abstract

The Δ15′(20′) double bond of anhydrovinblastine (1) is oxidized by various oxidants, in particular by air, to give the corresponding epoxide leurosine (5); the question of leurosine (5) being an artefact is discussed.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1978, 102-103

Antitumour alkaloids of the vinblastine-type: is leurosine an artefact?

N. Langlois and P. Potier, J. Chem. Soc., Chem. Commun., 1978, 102 DOI: 10.1039/C39780000102

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