Determination of metiamide (SKF 92058) by differential-pulse polarography
Abstract
Metiamide (SKF 92058) undergoes anodic oxidation at the dropping-mercury electrode with the formation of mercury salt(s). Differential-pulse polarographic analysis has been carried out on several formulations in 0.1 M sodium hydroxide solution as supporting electrolyte using the peak corresponding to this oxidation process. The effects of degradation products and anti-oxidants on this determination have been investigated in addition to comparing the polarographic method with one involving high-performance liquid chromatography.