Conformation of various tetracycline species determined with the aid of a nuclear magnetic resonance relaxation probe
Abstract
The aqueous solution conformation of the gadolinium (III) complexes of the protonated, neutral, and singly deprotonated tetracycline species have been determined. The complete proton resonance assignment for each species is given. Evidence is presented for the site(s) of protonation or deprotonation as well as for intramolecular hydrogen bonding.