The reduction of some chiral γ-hydroxy-ketones by amalgamated zinc–hydrochloric acid (Clemmensen reduction) has been studied. Reduction of the carbonyl group occurs rapidly with retention of configuration at the carbinol carbon atom. This result invalidates part of an earlier hypothesis.
B. R. Davis, G. W. Rewcastle, R. J. Stevenson and P. D. Woodgate, J. Chem. Soc., Perkin Trans. 1, 1977, 2148 DOI: 10.1039/P19770002148
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