Mono-C-alkylation of a number of β-dicarbonyl compounds using alkyl iodides and tetra-alkylammonium fluorides is described. Yields are high with primary iodides and isopropyl iodide, but much lower with s-butyl and t-butyl iodides. The reactions occur under mild conditions with no apparent O-alkylation or other competing reactions.
J. H. Clark and J. M. Miller, J. Chem. Soc., Perkin Trans. 1, 1977, 1743 DOI: 10.1039/P19770001743
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