Preparation and reactions of 2-amino- and 2-acetamido-4-methylthiazole-5-carbohydrazides: revision of the literature

Abstract

The literature reports that 2-acetamido-4-methylthiazole-5-carbohydrazide is formed by treating ethyl 2-acetamido-4-methylthiazole-5-carboxylate with hydrazine are incorrect: ethyl 2-amino-4-methylthiazole-5-carboxylate is produced in this reaction. Since authentic 2-acetamido-4-methylthiazole-5-carbohydrazide has a m.p. 87° higher than that of the compound described as such in the literature, the status of the substances prepared from the latter must be questioned.