Total synthesis of clavulanic acid analogues via isomerisation of 7-oxo-4-oxa-1-azabicyclo[3.2.0]hept-2-enes
Abstract
Sodium Z-3-benzylidene-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate (1b), a novel clavulanic acid analogue, has been prepared via the isomerisation of the bicycloheptane (2a).