One-step synthesis of 8-chloroflavins by the cyclization of 5-nitro-6-(N-substituted-anilino)uracils with the Vilsmeier reagent. Vilsmeier reagent as a reducing agent
Abstract
Treatment of 5-nitro-6-(N-substituted-anilino)-uracils with the Vilsmeier reagent (dimethylformamide–phosphorus trichloride oxide) gave the corresponding 8-chloroflavins; the Vilsmeier reagent acted as a reducing agent as well as a dehydrating and chlorinating agent.