N 2 -Methylguanosine (1c) may be prepared in satisfactory yield by treating the protected guanosine derivative (5a) with diazomethane and then removing the protecting groups; (5a), which readily reacts with dimethylamine to give (5c), may be prepared from (4a) in good yield.
P. K. Bridson, W. Markiewicz and C. B. Reese, J. Chem. Soc., Chem. Commun., 1977, 447 DOI: 10.1039/C39770000447
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