Metal ion- and pyridoxal-catalysed transamination and dephosphonylation of 2-amino-3-phosphonopropionic acid. A new phosphonatase model
Abstract
Vitamin B6 and metal ion-catalysed transamination of 2-amino-3-phosphonopropionic acid (APP) results in initial formation of the metal chelate of the pyridoxal–APP Schiff base, followed successively by transamination to the ketimine chelate, dephosphonylation, reverse transamination, and finally hydrolysis to alanine and pyridoxal.