Preparation of isoxazoline N-oxide derivatives from a nitro-sugar and S-ylides
Abstract
Axial attack predominates over equatorial attack in the addition of dimethylsulphoxonium methylide and ethyl dimethylsulphuranylideneacetate to the nitro-sugar (1); axial attack selectively gave the 1,4-addition products (3) and (6), whereas equatorial attack afforded the 1,2-addition products (2) and (4), respectively.