Issue 10, 1976

Proton magnetic resonance spectra of amino-acids and peptides relevant to wool structure. Part VI. Relative residence times of peptides of histidine, tryptophan, and valine

Abstract

100 and 220 MHz 1H n.m.r. spectra have been recorded, over the temperature range 291–358 K, for acidic and basic D2O solutions of nine dipeptides and three tripeptides containing histidyl, tryptophyl, and valyl groups. Analysis of the spectra enabled the populations of the side-chain (Cα–Cβ bond) rotamers to be calculated from the vicinal coupling constants. For the histidyl and tryptophyl peptides in acid and base, all rotamers are appreciably populated. In the range studied, the rotamer populations of the histidyl residues are almost unaffected by increase of temperature, while for Gly-Tyr and Gly-Trp-Gly there is a slight tendency for the preponderance of rotamer (I) to lessen. In the valyl peptides examined, the population of the rotamer with the vicinal hydrogens trans was greatest for acidic solutions of peptides with the valyl residue carbon terminal.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1976, 1190-1192

Proton magnetic resonance spectra of amino-acids and peptides relevant to wool structure. Part VI. Relative residence times of peptides of histidine, tryptophan, and valine

B. J. Dale and D. W. Jones, J. Chem. Soc., Perkin Trans. 2, 1976, 1190 DOI: 10.1039/P29760001190

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