A regio- and stereo-selective free radical bromination of steroidal αβ-unsaturated ketones
Abstract
The light catalysed bromination of αβ-unsaturated steroidal ketones has been studied in the presence of an epoxide as a hydrobromic acid scavenger. In these conditions an uncommon regio- and stereo-selectivity for a radical reaction is observed and only 6β-brominated products are formed.