Enkephalin. Synthesis of two pentapeptides isolated from porcine brain with receptor-mediated opiate agonist activity

Abstract

The synthesis and purification of L-tyrosylglycylglycyl-L-phenylalanyl-L-methione (methionine⁵-enkephalin) and L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine (leucine⁵-enkephalin) are described. These synthetic peptides were identical in both physical and biological characteristics with the constituents of enkephalin, a material isolated from porcine brain with potent receptor-mediated opiate agonist activity.