Syntheses towards the carbohydrate moiety of lincomycin
Abstract
A key intermediate in the synthesis of the antibiotic lincomycin, 6-acetamido-6,8-dideoxy-1,2:3,4-di-O-isopropylidene-α-D-erythro-D-galacto-octopyranose (10), has been synthesised from cis-6,7,8-trideoxy-1,2:3,4-di-O-isopropylidene-7-C-nitro-α-D-galacto-oct-6-enose (3). The amino-group at C-6 was introduced by two different procedures.