The synthesis of (±)-phyllodulcin (12), a sweet principle of Hydrangea serrata Seringe var. thunbergii Sugimoto, from 3-(3-benzyloxy-4-methoxyphenyl)prop-2-enal modelled on the polyketide mode of biosynthesis is described.
N. Takeuci, M. Murase, K. Ochi and S. Tobinaga, J. Chem. Soc., Chem. Commun., 1976, 820b DOI: 10.1039/C3976000820B
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