Issue 23, 1976

Protection of cysteine and histidine by the diphenyl-4-pyridylmethyl group during peptide synthesis

Abstract

The diphenyl-4-pyridylmethyl group provides acid-stable protection of the thiol group of cysteine and the imidazole-nitrogen of histidine; it is removed by reductive methods (including electrolytic reduction) and from thiols by mercury(II) acetate and by iodine.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1976, 980-981

Protection of cysteine and histidine by the diphenyl-4-pyridylmethyl group during peptide synthesis

S. Coyle and G. T. Young, J. Chem. Soc., Chem. Commun., 1976, 980 DOI: 10.1039/C39760000980

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