The hydroxymethylation of the ester enolate derived from the ester (2) provided the hydroxymethylated adducts (3) and (4) both of which have been successfully converted into 12-hydroxymethylprostaglandin F2α methyl ester(1).
P. A. Grieco, C. J. Wang and F. J. Okuniewicz, J. Chem. Soc., Chem. Commun., 1976, 939 DOI: 10.1039/C39760000939
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