The total synthesis of 12-fluoroprostaglandin F2α methyl ester (1) from norbornadiene is described which involves the fluorination of the enolate derived from the ester (3) with perchloryl fluoride.
C. J. Wang, P. A. Grieco and F. J. Okuniewicz, J. Chem. Soc., Chem. Commun., 1976, 468 DOI: 10.1039/C39760000468
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