Synthesis of 3-substituted 1,2-benzodiazepines via 3H-1,2-benzodiazepine N-oxides
Abstract
Treatment of 3H-1,2-benzodiazepine 2-oxides (2), prepared from 3H-1,2-benzodiazepines (1) and m-chloroperbenzoic acid, with bases and acids such as alkoxides, carbanions, hydrogen chloride, and acetic acid, affords the corresponding 3-substituted 1,2-benzodiazepines (5)–(8) in moderate yields.