The quantitative determination of amitriptyline extracted from biological fluids has been achieved using an oxidation procedure. By use of selective oxidation methods a knowledge of the levels of 10-hydroxylated metabolites of amitriptyline can be obtained. Some evidence is presented that dehydroamitriptyline, or its demethylated derivatives, are natural metabolites of amitriptyline in man.
B. Caddy, F. Fish and J. Tranter, Analyst, 1976, 101, 244 DOI: 10.1039/AN9760100244
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