Synthesis of 1α-hydroxycorticosterone
Abstract
1α-Hydroxycorticosterone (5), previously isolated from the skate (genus Raja), has been prepared from corticosterone 21-acetate via its 1,2,6,7-tetradehydro- and 1α,2α-epoxy-6,7-didehydro-derivatives. The configuration at C-1 has been established by polarimetry.