As potential specific inhibitors of sterol biosynthesis, two steroidal allenes, stigmasta-5,24(28),28-trien-3β-ol (6) and cholesta-5,23,24-trien-3β-ol (22), have been synthesized via a reductive SN2′ reaction(lithium aluminium hydride–aluminium chloride) of the corresponding αβ-acetylenic alcohols.
Y. Fujimoto, M. Morisaki and N. Ikekawa, J. Chem. Soc., Perkin Trans. 1, 1975, 2302 DOI: 10.1039/P19750002302
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