Determination of the stereochemistry of the product of rearrangement of penicillin G with methyl chloroformate by total synthesis
Abstract
Separate stereospecific syntheses of the product [4-isopropylidene-2-(2-methylthio-1-phenylacetamidovinyl)-oxazol-5-(4H)-one] from the rearrangement of penicillin G with methyl chloroformate and of its geometric isomer have defined the former as the Z-isomer.
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