Synthesis of 18-substituted steroids. Part I. 18,21-Dihydroxypregn-4-ene-3,20-dione (18-hydroxydeoxycorticosterone)
Abstract
The reaction between an 18-hydroxypregnan-20-one [in the hemiacetal form (1b)] and lead tetra-acetate gives the 21-acetoxy-derivative in high yield, opening the way to a new and efficient synthesis of 18-hydroxydeoxycorticosterone. The preparation of the 1,2-didehydro-derivative of 18-hydroxydeoxycorticosterone is also described.