Synthesis of 1-aryloxymethyl- and 1-arylthiomethyl-imidazoles
Abstract
A convenient synthesis of 1-aryloxymethylimidazoles (1; X = O) from sodium imidazolide, dichloromethane or bromochloromethane, and sodium phenolates is described. 1-Aryloxymethyl- and 1-arylthiomethyl-imidazoles were also prepared by alkylation of imidazole with chloromethyl ethers or chloromethyl thioethers.