Issue 9, 1975

Structures of the aminoglycoside antibiotics 66–40B and 66–40D produced by Micromonospora inyoensis

Abstract

The novel amino-glycoside antibiotics 66–40B and 66–40D produced as minor components by fermentation of Micromonospora inyoensis have been shown to be O-2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-3-methylamino-α-D-xylopyranosyl-(1→6)]-2-deoxy-D-streptamine and O-2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-3-methylamino-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine, respectively. The novel 3-deoxy-3-methylamino-β-L-arabinopyranosyl sugar unit of 66–40D has not previously been found in any amino-glycoside antibiotic. Both 66–40B and D exhibit broad spectrum antibacterial activity.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1975, 814-818

Structures of the aminoglycoside antibiotics 66–40B and 66–40D produced by Micromonospora inyoensis

D. H. Davies, D. Greeves, A. K. Mallams, J. B. Morton and R. W. Tkach, J. Chem. Soc., Perkin Trans. 1, 1975, 814 DOI: 10.1039/P19750000814

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