Isolation and structure of coprine, a novel physiologically active cyclopropanone derivative from Coprinus atramentarius and its synthesis via 1-aminocyclopropanol
Abstract
Coprine, the ‘antabuse’-like principle of the inky cap mushroom Coprinus atramentarius has been isolated; its structure, which includes a cyclopropanone equivalent, has been determined and it has been synthesised from 1-hydroxycyclopropylammonium chloride via the unstable 1-aminocyclopropanol.