Alkoxide ion vs. methylthiolate ion displacement in the Grignard reaction on O-alkyl S-methyl phenylphosphonothiolate
Abstract
MeMgI reacts with O-alkyl S-methyl phenylphosphonothiolates to displace either the methylthio group with retention of configuration at phosphorus or the alkoxy group with inversion, the competition depending on the nature of the alkoxy group.