Potentially carcinogenic cyclopenta[a]phenanthrenes. Part IX. Characterisation of a 5,10-epoxybenzocyclodecene as a major urinary metabolite of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]-phenanthren-17-one

Abstract

The major urinary metabolite of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one (Ib) produced by the rat is shown by chemical and spectral examination to possess the novel structure 8,9-epoxy-1α,2β,15ζ-trihydroxy-11-methyl-8,9-secogona-3,5,7,9,11,13-hexaen-17-one (II).