Issue 0, 1974

Heterocyclic studies. Part XXXII. Some 5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-ones

Abstract

Condensation of 6-(substituted amino)-5-aminopyrimidine-4(3H)-thiones with chloroacetic acid (or its ethyl ester), ethyl bromomalonate, or ethyl α-bromopropionate yielded 4-(substituted amino)-5H-pyrimido[4,5-b][1,4]-thiazin-6(7H)-ones with no substituent, an ethoxycarbonyl group, or a methyl group, respectively, in the 7-position. Some of the compounds were converted into 5-methyl, 5-benzyl, or 5-allyl derivatives. 1H N.m.r., u.v., and i.r. spectroscopy showed that the pyrimidothiazines were 5H-6(7H)-ones rather than other possible tautomers. Ionisation of the compounds is discussed and mass spectra are recorded and discussed.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1974, 1805-1812

Heterocyclic studies. Part XXXII. Some 5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-ones

J. Clark and I. W. Southon, J. Chem. Soc., Perkin Trans. 1, 1974, 1805 DOI: 10.1039/P19740001805

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