Microbiological hydroxylation. Part XII. Comparative behaviour of D-homogonane (perhydrochrysene) ketones and steroids

Abstract

rac-D-Homogonanes, with one and two oxygen substituents in positions comparable to those of certain C₁₉ steroids have been synthesised. When these C₁₈ compounds, lacking the steroid angular methyl groups, are incubated with cultures of Calonectria decora and Rhizopus nigricans, the patterns of hydroxylation observed are closely analogous to those with the structurally related steroids.