The behaviour of some N-benzoylnicotinamide salts with nucleophiles in base is described. In each case addition to C-4 of the pyridine ring occurs, followed by cyclisation to a 2,7-naphthyridone. The reaction with ethyl aceto-acetate unexpectedly gave 3-substituted 2,7-naphthyridones.
M. N. Palfreyman and K. R. H. Wooldridge, J. Chem. Soc., Perkin Trans. 1, 1974, 57 DOI: 10.1039/P19740000057
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