Issue 15, 1974

Synthesis of α-hydroxy-β-acetylenic acids and their oxidation by and inactivation of flavoprotein oxidases

Abstract

Five α-hydroxy-β-acetylenic acids have been prepared; all are active substrates for a mammalian flavoprotein oxidase, with only the C4 molecule a particularly effective suicide substrate.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1974, 597-598

Synthesis of α-hydroxy-β-acetylenic acids and their oxidation by and inactivation of flavoprotein oxidases

T. Cromartie, J. Fisher, G. Kaczorowski, R. Laura, P. Marcotte and C. Walsh, J. Chem. Soc., Chem. Commun., 1974, 597 DOI: 10.1039/C39740000597

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