Reactions of heterocycles with thiophosgene. Part II. The chemistry of 3-formylquinoline-2(1H)-thione
Abstract
Reaction of o-isothiocyanato-trans-cinnamaldehyde, a scission product from quinoline and thiophosgene, with diethyl sodiomalonate gives 3-formylquinoline-2(1H)-thione. This compound has been used as an intermediate in the synthesis of thieno[2,3-b]quinolines, isothiazolo[5,4-b]quinoline, and some 2,3-substituted quinolines.