Issue 0, 1973

Synthesis of [3,5-3H2-Tyr23]-β-corticotrophin-(1–24)-tetracosapeptide

Abstract

The synthesis is described of β-corticotrophin-(1–24)-tetracosapeptide labelled with tritium in the tyrosine residue at position 23 to a specific radioactivity of 46 Ci mmol–1 by reductive deiodination of a protected precursor. Evidence for the integrity of the final product is provided by amino-acid analysis, column and thin-layer chromatography, and bioassay, supported by chemical and enzymic analytical data on the protected precursor and the derived tetracosapeptide containing di-iodotyrosine.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1973, 2875-2879

Synthesis of [3,5-3H2-Tyr23]-β-corticotrophin-(1–24)-tetracosapeptide

D. E. Brundish and R. Wade, J. Chem. Soc., Perkin Trans. 1, 1973, 2875 DOI: 10.1039/P19730002875

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements