An alkali-labile substituted benzyloxycarbonyl amino-protecting group
Abstract
4-Isopropyloxycarbonyloxybenzyloxycarbonyl, Z(4-PriOCO), a new amino-protecting group stable under the conditions which cause cleavage of the t-butoxy-carbonyl and 2-(p-biphenylyl)isopropyloxycarbonyl groups, can be removed in a slightly alkaline medium via a 1,6-elimination, by hydrogenolysis, or by HBr in acetic acid.
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