Dopastin has been synthesised from L-valinol by an 8-step procedure, in which the key stage involves oxaziran formation followed by hydrolysis with Dowex 50W, with retention of the absolute configuration of the starting material in the final product.
M. Ohno, H. Iinuma, N. Yagisawa, S. Shibahara, Y. Suhara, S. Kondo, K. Maeda and H. Umezawa, J. Chem. Soc., Chem. Commun., 1973, 147 DOI: 10.1039/C39730000147
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