Novel conversion of penicillins into cephalosporins
Abstract
A new antibacterially active cephalosporin 3-benzyl-7β-(2-thienylacetamido)ceph-3-em-4-carboxylic acid, has been prepared from the 1,2-seco-penicillin (3), using an intramolecular Wittig reaction to construct the dihydrothiazine ring.