Titrimetric determination of amphetamine sulphate in tablets

Abstract

A titrimetric method is described for the determination of amphetamine sulphate in solutions, which can be applied to the analysis of pharmaceutical products. The analysis, which is based on bromination of the primary amino group followed by iodimetric determination, can be carried out by amperometric titration or titration by use of an indicator. The principal advantages of the method are that it is rapid and relatively easy to perform, that it has high sensitivity, which permits the analysis of individual tablets, and that inexpensive apparatus can be used.