SCHEDULED MAINTENANCE
Using ergosterol acetate as starting material, 22-hydroxylated analogues of 22,23-dihydroergosterol have been prepared via(i) selective epoxidation of the 22,23-double bond and (ii) Grignard reaction on the hexanor-22-aldehyde. (22S)-Hydroxyvitamin D4, produced upon irradiation of (22S)-22,23-dihydro-22-hydroxyergosterol, showed no significant antirachitic activity in rats.
D. R. Crump, D. H. Williams and B. Pelc, J. Chem. Soc., Perkin Trans. 1, 1973, 2731 DOI: 10.1039/P19730002731
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