The nitration of 2-pyridone yields largely the 3-nitro-derivative in low acidity media and largely the 5-nitro-compound in high acidity media. However, both reactions occur on the free base species. This behaviour is compared with similar phenomena in the literature.
A. G. Burton, P. J. Halls and A. R. Katritzky, J. Chem. Soc., Perkin Trans. 2, 1972, 1953 DOI: 10.1039/P29720001953
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