The product of a Mannich reaction on butane-2,3-dione depended upon the secondary base employed. With dimethylamine the product was 2,4-bisdimethylaminomethyl-2-methylfuran-3(2H)-one (II). With morpholine or N-methylpiperazine, a bis Mannich base derived from 2,5-dimethylbenzene-1,4-diol was obtained while pyrrolidine was the only base investigated which gave the expected open chain bis Mannich derivative.
J. V. Greenhill, P. H. B. Ingle and M. Ramli, J. Chem. Soc., Perkin Trans. 1, 1972, 1667 DOI: 10.1039/P19720001667
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