A new synthesis of disubstituted 8-aminopurine derivatives
Abstract
Treatment of 6-amino-5-nitrosopyrimidines with the Vilsmeier reagent (dimethylformamide and phosphorus oxychloride) afforded in general the respective 8-dimethylaminopurines; treatment of 6-amino-4-hydroxy-2-methyl-5-nitrosopyrimidine gave 2-chloromethyl-8-dimethylamino-6-hydroxypurine.