A computer method for the spectrophotometric determination of overlapping pKa values

Abstract

A least-squares computer method has been developed to obtain two pK_a values from spectrophotometric data in instances when the values are so close together that the calculations usually applied for individual pK_a values are not appropriate. A scaling procedure improves the condition of the matrix that is constructed in solving the sets of simultaneous equations. Two examples of applications of the method are given.