Slow ring-inversion of the nine-membered lactam in 4-azabicyclo[5,2,2]-undeca-8,10-dien-3-one systems

Abstract

The kinetic parameters for hindered inversion of the nine-membered lactam ring in 4-azabicyclo[5,2,2]undeca-8,10-dien-3-one systems have been determined by n.m.r. total line-shape analysis. These data may provide an example of hindered ring-inversion of a medium-sized ring caused by hindered rotation of the amide group.