Steroid conjugates. Part II. Synthesis of 5β-pregnane-3α,20α-diol 20-monosulphate
Abstract
The title compound has been prepared from 5β-pregnane-3α-20α-diol by way of the 3-tetrahydropyranyl ether. During unsuccessful approaches to the same conjugate, reduction of the keto-group of 20α-hydroxy-5β-pregnan-3-one sulphate with borohydride was found to be inhibited by the pyridinium sulphate residue.